Can you provide a link to the website you have in mind? That would be helpful in understanding exactly what it is you are looking to do. The most suitable approach will depend on whether the website has a public API. If it does, you should be able to retrieve/submit data via the API. Otherwise, the approach will probably be to retrieve and parse the HTML. For displaying the UI, you can use either QtGui widgets or QML. In your case, I would probably use Python with the Qt bindings for the backend code.