Well, 256 bytes don't hold very impressive images or sounds. that's for sure
how does read/write cycles in NFS tags and EEPROMs compare, when they are used to periodically store temporary data?
Remember that the VDD in toh is 3.3V, and I2C levels are 1.8V CMOS, so the EEPROM might not talk with you.
Now you'd need to write up a daemon that gets kicked when an EEPROM of the signature you have gets inserted to I2C...