I came across a little trick to get things aligned, but it is a little complicated and not really what you might look for:

In case you move things from one desktop to another, the OS positions them for you on the 'new' desktop you move them to.
If e.g. you move contact or application shortcuts from one desktop to another, they get aligned pretty nice, depending on what already is on the other desktop and where (speaking of the vertical axis) you move them.

Did the trick for one of my screens

Best regards,
Corwin