To summarize: This means allowing an emulator to accept multiple keypresses, and interpret RIGHT+UP as diagonal. The rest of it can be left to user keymapping.

I had the same idea SavageD. Many games have player running left and right, but require a well-timed up or down action. So allowing player to hold "E" for right and roll the thumb to roll over "W" for a quick 'up' while holding down "E" could be the most playable solution.

You can try out all of these ideas right now, using FMS's VGBA emulator, for example.

No thanks for posting to an unrelated thread, though.