Here is Picodrive (.deb package) :

https://www.dropbox.com/scl/fi/93u41...kg8hnsgw7&dl=0

It should work out of the box but you need to manually change the config file permission:
Settings are already optimized: sound and frameskip are deactivated by default and Megadrive games run at 50-60 fps.
To play with sound just turn ON sound and set frameskip to 1. (30 fps)
Don't forget to save settings otherwise there are ignored.

For 32X games sound is laggy, just turn it off and set frameskip to 1. (25 fps)
Update: with the new ddx driver, it runs now at 40-50 fps (frameskip 0)

(note: by default START button is linked to BACKSPACE key)
This port is based on the last 1.92.3 version, not the old maemo one.